Press & Publications.
Treating anaemia with gene scissors
ETH Zurich molecular biologist Mandy Boontanrart is researching gene therapies that could be used to cure two of the most common types of inherited anaemia. She has now developed a promising approach for so-called beta-hemoglobinopathies.
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Engineering of the endogenous HBD promoter increases HbA2
This study presents the important finding that gene editing could be used to activate δ-globin expression to treat disorders of red blood cell synthesis. The evidence supporting the claims of the authors is convincing…
Hoping to Heal
With her start-up Ariya Bio, Mandy Boontanrart aims to develop a therapy for severe blood diseases. Thanks to ground-breaking discoveries in genetic research, she may not be far from making her vision come true.
Delta Force: Scientists Promote Novel Globin Genetic Therapy for Sickle Cell Disease
Mandy Boontanrart, PhD, a postdoc at ETH Zurich in Switzerland, has a particularly personal motivation for her research on a novel genetic therapy for sickle cell disease…
“A major advantage compared to the gamma-globin approach is that “the delta globin gene is poised for transcription, as it is very close to the actively produced adult beta globin gene, so this could be very advantageous as this strategy is explored further.””
— Vijay Sankaran, MD PhD
Boston Children’s Hospital
Harvard Medical School
Genetic Engineering & Biotechnology News